apalutamide will lessen the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medication that are CYP2C19 substrates can result in decrease publicity to these remedies.diazepam will raise the degree or impact of ruxolitinib by i